Trifluoroacetic acid → HCID 178457231、化合物

HRID 25583

反応式

HRID 25583 の反応式
C(O[C:6](=O)[N:7]([C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]#[C:16][CH2:17][N:18]([CH2:20][CH:21]=[CH2:22])[CH3:19])[CH2:11][CH2:10]1)C)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:20]([N:18]([CH3:19])[CH2:17][C:16]#[C:15][C@H:12]1[CH2:13][CH2:14][C@H:9]([NH:7][CH3:6])[CH2:10][CH2:11]1)[CH:21]=[CH2:22]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 178457235HCID 178457235、化合物

生成物 1

HCID 178457231HCID 178457231、化合物収率 107.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 200 mg (0.62 mmol) of trans-{4-[3-(Allyl-methyl-amino)-prop-1-ynyl]-cyclohexyl}-methyl-carbamic acid tert-butyl ester in 3.5 ml CH2Cl2 was treated at 0° C. with 1.7 ml TFA (for 20 min). After 30 min at this temperature, the reaction mixture was evaporated, treated with 1 N NaOH/CH2Cl2 (3×). The organic phase was dried over Na2SO4 and evaporated to yield 147 mg (quantitative) of trans-{4-[3-(Allyl-methyl-amino)-prop-1-ynyl]-cyclohexyl}-methyl-amine, MS: 221 (MH+).

後処理

  1. customthe reaction mixture was evaporated
  2. additiontreated with 1 N NaOH/CH2Cl2 (3×)
  3. dry with materialThe organic phase was dried over Na2SO4
  4. customevaporated

出典と根拠

ORDレコード
ord-581b627cf2ae4cea946383d4cc2d58e3
出典データセット
uspto-grants-2005_02
特許番号
US06858651B2

関連ノート

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