Dodecane, 1-isocyanato- → N-Octadecyl-N-(D-glucopyranosyl)-N'-dodecylurea

HRID 255874

反応式

HRID 255874 の反応式
[CH2:1]([NH:19][CH:20]1[O:28][C@H:27]([CH2:29][OH:30])[C@@H:25]([OH:26])[C@H:23]([OH:24])[C@H:21]1[OH:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH2:31]([N:43]=[C:44]=[O:45])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42]>O1CCCC1.C(O)C>[CH2:1]([N:19]([CH:20]1[O:28][C@H:27]([CH2:29][OH:30])[C@@H:25]([OH:26])[C@H:23]([OH:24])[C@H:21]1[OH:22])[C:44]([NH:43][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])=[O:45])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

参加物

5

反応物 2

HCID 77873Dodecane, 1-isocyanato-HCID 13361749N-octadecylglucopyranosylamine

生成物 1

HCID 13517874N-Octadecyl-N-(D-glucopyranosyl)-N'-dodecylurea

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

9 g of the compound from Example 1 are suspended in 160 ml of tetrahydrofuran and 40 ml of ethanol. 4.3 g of dodecyl isocyanate, dissolved in 20 ml of tetrahydrofuran, are added dropwise to this suspension in the course of 20 minutes. When the reaction has ended, the mixture is evaporated in vacuo and the resulting syrup is purified by column chromatography (mobile phase methylene chloride/methanol, 15:1)

後処理

  1. additionare added dropwise to this suspension in the course of 20 minutes
  2. customthe mixture is evaporated in vacuo
  3. customthe resulting syrup is purified by column chromatography (mobile phase methylene chloride/methanol, 15:1)

出典と根拠

ORDレコード
ord-991551d7b76645ff896dda6c416665b0
出典データセット
uspto-grants-1987_10
特許番号
US04699899

関連ノート

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