2-Amino-4-methylpyridine → 4-Methyl-2-phthalimidopyridine

反応式

[NH2:1][C:2]1[CH:7]=[C:6]([C:8](Cl)(Cl)Cl)[CH:5]=[CH:4][N:3]=1.NC1C=C(C)C=CN=1.[C:20]1(=O)[O:25][C:23](=[O:24])[C:22]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:21]12>>[CH3:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:1]2[C:23](=[O:24])[C:22]3=[CH:26][CH:27]=[CH:28][CH:29]=[C:21]3[C:20]2=[O:25])[CH:7]=1

参加物

反応物 3

HCID 15332-Amino-4-methylpyridine

HCID 6811Phthalic Anhydride

HCID 137101174-(Trichloromethyl)pyridin-2-amine

生成物 1

HCID 109990494-Methyl-2-phthalimidopyridine

実験手順

A process for the preparation of 2-amino-4-trichloromethylpyridine of the formula I, wherein 2-amino-4-picoline is reacted with phthalic anhydride to give 4-methyl-2-phthalimidopyridine, the latter is chlorinated and the product is hydrolyzed.

出典と根拠

ORDレコード: ord-109dcc2773f8420f9acc4994d6793d4d
出典データセット: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04699983

反応ノート

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