Sodium Hydroxide → alpha-{6-[1-Carboxy-3-phenylpropylamino]-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl}acetic acid
反応式
C([O:3][C:4]([CH:6]([NH:15][CH:16]1[CH2:22][S:21][CH:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:19][N:18]([CH2:29][C:30]([OH:32])=[O:31])[C:17]1=[O:33])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])C.[OH-].[Na+]>>[C:4]([CH:6]([NH:15][CH:16]1[CH2:22][S:21][CH:20]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:19][N:18]([CH2:29][C:30]([OH:32])=[O:31])[C:17]1=[O:33])[CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)([OH:5])=[O:3]参加物
3
実験手順
0.17 g of α-{6-[1-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl}acetic acid (prepared as described in Example 9 above) was hydrolysed with caustic soda in the manner described in Example 5, giving the title compound as a powder in a yield of 0.13 g.
出典と根拠
- ORDレコード
- ord-d30b23a2f6a843cc81315baaf5a22acf
- 出典データセット
- uspto-grants-1987_10
- 特許番号
- US04699905
反応ノート
読み込み中…