N-bromobutanimide → 4-Bromomethyl-2-fluoropyridine

HRID 256171

反応式

HRID 256171 の反応式
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[Br:9]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:9][CH2:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([F:1])[CH:7]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 27374032-Fluoro-4-methylpyridine

生成物 1

HCID 139851684-Bromomethyl-2-fluoropyridine収率 24.4%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

By the method of Example 20, 10 g (0.09 mole) of 2-fluoro-4-methylpyridine and 16 g (0.09 mole) of N-bromosuccinimide were reacted in 90 ml of carbon tetrachloride to produce 4.18 g 4-bromomethyl-2-fluoropyridine. The ir, proton nmr, and 19F nmr spectra were all consistent with the proposed structure.

出典と根拠

ORDレコード
ord-34c5140a392d4dbeb1659ba46ee7b0da
出典データセット
uspto-grants-1987_10
特許番号
US04701464

関連ノート

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