関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 1-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid | HCID 688396 | — |
| 反応物 | Bis(1-methylpiperazin-2-yl)alumanylium;hydride | HCID 18792082 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (1-Formylcyclopropyl)carbamic acid tert-butyl ester | HCID 10352385 | — |
反応手順
N-Boc-1-amino-1-cyclopropanecarboxylic acid is dissolved in tetrahydrofuran and stirred at 0° C. under argon. Bis(N-methylpiperazinyl)aluminum hydride is added and the reaction mixture is heated to reflux overnight. Ether is then added, and the excess hydride is quenched with saturated NaCl. The aqueous phase is separated and extracted with ether. The combined organic phases are washed with 2M NaOH, 2M HCl and saturated NaCl. The solution is dried over Na2SO4 and evaporated to yield N-Boc-1-amino-1-cyclopropanecarboxaldehyde.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04701552 |
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| 出典データセット | uspto-grants-1987_10 |
|---|
| ORD ID | ord-09ba152299a341178c810e4e2124543b |
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| 出典メモ | uspto-grants-1987_10 |
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