反应详情

温度

0 °C

N-Boc-1-amino-1-cyclopropanecarboxylic acid is dissolved in tetrahydrofuran and stirred at 0° C. under argon. Bis(N-methylpiperazinyl)aluminum hydride is added and the reaction mixture is heated to reflux overnight. Ether is then added, and the excess hydride is quenched with saturated NaCl. The aqueous phase is separated and extracted with ether. The combined organic phases are washed with 2M NaOH, 2M HCl and saturated NaCl. The solution is dried over Na2SO4 and evaporated to yield N-Boc-1-amino-1-cyclopropanecarboxaldehyde.

1. temperaturethe reaction mixture is heated
2. temperatureto reflux overnight
3. customthe excess hydride is quenched with saturated NaCl
4. customThe aqueous phase is separated
5. extractionextracted with ether
6. washThe combined organic phases are washed with 2M NaOH, 2M HCl and saturated NaCl
7. dry with materialThe solution is dried over Na2SO4
8. customevaporated