Water → Tetrahydro-2h-thiopyran-4-yl 4-methylbenzenesulfonate

HRID 256285

反応式

HRID 256285 の反応式
[S:1]1[CH2:6][CH2:5][CH:4]([OH:7])[CH2:3][CH2:2]1.[CH3:8][C:9]1[CH:14]=[CH:13][C:12]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:10]=1.O>N1C=CC=CC=1>[CH3:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([O:7][CH:4]2[CH2:5][CH2:6][S:1][CH2:2][CH2:3]2)(=[O:17])=[O:16])=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 576296Tetrahydro-2H-thiopyran-4-ol

生成物 1

HCID 270400Tetrahydro-2h-thiopyran-4-yl 4-methylbenzenesulfonate収率 142%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 4.1 g (0.015 mole) of tetrahydro-4H-thiopyran-4-ol in 40 mL of pyridine, cooled in an ice bath, was added 2.90 g (0.15 mole) of 4-methylphenylsulfonyl chloride, and the reaction mixture was stirred at room temperature for 16 hours. The mixture was poured into a mixture of ice and water, and the whole extracted with diethyl ether. The organic phase was washed with water then with a 10% aqueous solution of sodium hydroxide, dried, and concentrated to give 5.8 g of product as an oil.

後処理

  1. extractionthe whole extracted with diethyl ether
  2. washThe organic phase was washed with water
  3. dry with materialwith a 10% aqueous solution of sodium hydroxide, dried
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-7c12282e7d874b62b9f30688a8362156
出典データセット
uspto-grants-1987_10
特許番号
US04702763

関連ノート

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