Ethyl 2-(2-formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetate → 2-(2-Formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetic acid
反応式
[CH:1]([NH:3][C:4]1[S:5][C:6]([Br:18])=[C:7]([C:9](=[N:15][O:16][CH3:17])[C:10]([O:12]CC)=[O:11])[N:8]=1)=[O:2]>[OH-].[Na+]>[CH:1]([NH:3][C:4]1[S:5][C:6]([Br:18])=[C:7]([C:9](=[N:15][O:16][CH3:17])[C:10]([OH:12])=[O:11])[N:8]=1)=[O:2]参加物
3
実験手順
1N-Aqueous sodium hydroxide (290 ml.) was added dropwise to an aqueous suspension (325 ml.) of ethyl 2-(2-formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetate (syn isomer, 32.5 g.) under ice-cooling, and the mixture was treated in a similar manner to that of Preparation 2-(2) to give 2-(2-formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetic acid (syn isomer, 21.9 g.), m.p. 165° to 167° C.
後処理
- temperaturecooling
- additionthe mixture was treated in a similar manner to that
- customof Preparation 2-(2)
出典と根拠
- ORDレコード
- ord-7c0361784a5e45438929994e6df34a92
- 出典データセット
- uspto-grants-1987_10
- 特許番号
- US04703046
反応ノート
読み込み中…