Hydrochloric Acid → HCID 20759866、化合物
反応式
C([O:3][CH:4](OCC)[CH2:5][CH2:6][NH:7][C:8](=[O:37])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:36])[O:21][CH2:22][CH:23]1[C:35]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:29]2[C:24]1=[CH:25][CH:26]=[CH:27][CH:28]=2)C.Cl>O1CCCC1>[CH:25]1[C:24]2[CH:23]([CH2:22][O:21][C:20](=[O:36])[NH:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:8](=[O:37])[NH:7][CH2:6][CH2:5][CH:4]=[O:3])[C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[C:29]=2[CH:28]=[CH:27][CH:26]=1参加物
4
実験手順
By using an analogous procedure to that described for Reference Example 14, 9H-fluoren-9-ylmethyl 11-[(3,3-diethoxypropyl)amino]-1-oxoundecylcarbamate (480 mg, 0.87 mmol, obtained from Reference Example 29) in tetrahydrofuran (5 ml) was reacted with 0.5 N hydrochloric acid (4 ml) at room temperature for 5 hours. Purification by chromatography (flash column, silica gel, 75% ethyl acetate in hexanes) provided 9H-fluoren-9-ylmethyl-11-oxo-11-[(3-oxopropyl)amino]undecyl-carbamate (348 mg, 84%) as a white waxy solid.