反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:17][NH:18][CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(O)(=O)C.C([BH3-])#N.[Na+].[C:35]([O-:42])(=[O:41])/[CH:36]=[CH:37]/[C:38]([O-:40])=[O:39].C(O)(=O)/C=C/C(O)=O>>[C:35]([OH:42])(=[O:41])/[CH:36]=[CH:37]/[C:38]([OH:40])=[O:39].[CH3:17][N:18]([CH:13]1[CH2:14][CH2:15][N:10]([C:7]2[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[CH2:11][CH2:12]1)[CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1参加物
7
実験手順
2.5 g (11.4 mmol) of 1-(4-nitrophenyl)-4-piperidone, 1.5 g (11.4 mmol) of N-methyl-N-(2-phenylethyl)amine, 0.7 g (11.4 mmol) of acetic acid and 0.7 g (11.4 mmol) of sodium cyanoborohydride were reacted in a similar manner to Example 1. The product was converted into the fumarate with fumaric acid in a conventional manner. 2.8 g of 4-(N-methyl-N-(2-phenylethyl)amino)-1-(4-nitrophenyl)piperidine fumarate were obtained. Melting point 201°-202° C.
出典と根拠
- ORDレコード
- ord-0e21e3335dc744fabbd6631370a16d32
- 出典データセット
- uspto-grants-1993_11
- 特許番号
- US05260318
関連ノート
読み込み中…