Hydrochloric Acid → HCID 14010319、化合物

HRID 257150

反応式

HRID 257150 の反応式
O.[OH:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]([OH:11])[C:8]([O-:10])=[O:9])=[CH:5][CH:4]=1.[Na+].[OH-].[Na+].[CH2:17](Cl)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.Cl>O>[CH2:17]([O:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]([OH:11])[C:8]([OH:10])=[O:9])=[CH:5][CH:4]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 7503Benzyl ChlorideHCID 14798Sodium Hydroxide2 回HCID 236981332-Hydroxy-2-(4-hydroxyphenyl)acetic acid, sodium salt hydrate

生成物 1

HCID 14010319HCID 14010319、化合物収率 69%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A solution of 41.6 g (0.20 mol) of sodium 4-hydroxymandelate monohydrate, 9.6 g (0.24 mol) of sodium hydroxide and 27.9 g (0.22 mol) of benzyl chloride in 50 ml of water is stirred for 17 hours at 70° C. It is then diluted using 50 ml of water, and a further 4.0 g (0.10 mol) of sodium hydroxide are added. The reaction mixture is refluxed for one hour, then cooled and acidified using concentrated hydrochloric acid, and the product which has precipitated is filtered. The residue is washed with cold water and subsequently dried under a high vacuum. 35.6 g (69%) of 4-benzyloxymandelic acid, m.p. 148°-155° C., result.

後処理

  1. additionIt is then diluted
  2. temperatureThe reaction mixture is refluxed for one hour
  3. temperaturecooled
  4. customthe product which has precipitated
  5. filtrationis filtered
  6. washThe residue is washed with cold water
  7. customsubsequently dried under a high vacuum

出典と根拠

ORDレコード
ord-15c46ef995b14f4b98d4d42579242328
出典データセット
uspto-grants-1993_11
特許番号
US05260430

関連ノート

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