Methanesulfonyl chloride → HCID 54026786、化合物
反応式
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH3:6][O:7][C:8]([C:10]1([F:16])[CH2:14][CH2:13][CH2:12][CH:11]1[OH:15])=[O:9]>N1C=CC=CC=1>[CH3:6][O:7][C:8]([C:10]1([F:16])[CH2:14][CH2:13][CH2:12][CH:11]1[O:15][S:2]([CH3:1])(=[O:4])=[O:3])=[O:9]参加物
4
反応条件
- 温度
- 0 °C
実験手順
0.36 g (3 mmol) of methanesulfonyl chloride was added under ice cooling to a mixture of 0.5 g (3 mmol) of 1-fluoro-2-hydroxy-1-cyclopentanecarboxylic acid methyl ester in cis form (compound number 2a) synthesized in Example 1 and 2 ml of pyridine, and the mixture was stirred at 0° C. for 5 hours. The reaction solution was poured into a ice water and extracted with ether, and the ether layer was washed with cold water. The ether layer was dried over anhydrous magnesium sulfate and the solvent was distilled away to obtain 0.59 g (yield: 80%) of the desired 2-methanesulfonyloxy-1-fluoro-1-cyclopentanecarboxylic acid methyl ester in cis form (compound number 5a).