Bromine → 7-Bromo-5-chloro-2,3-dihydrobenzofuran

HRID 257516

反応式

HRID 257516 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.[Br:11]Br.S([O-])([O-])(=O)=S.[Na+].[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([Br:11])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1

参加物

5

反応物 3

HCID 24408BromineHCID 24477Sodium ThiosulfateHCID 5929645-Chloro-2,3-dihydro-1-benzofuran

生成物 1

HCID 197834187-Bromo-5-chloro-2,3-dihydrobenzofuran収率 92%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

To a stirred solution of (33) (1.84 g, 11.93 mmol) in acetic acid (10 ml) at 0° C., was slowly added a solution of bromine (1.24 ml, 24 mmol) in acetic acid (5 ml). The reaction mixture was stirred at room temperature for 4.5 h. A 10% sodium thiosulphate solution (70 ml) was added and the mixture stirred for 10 min. The bulk of the solvent was evaporated in vacuo. The resulting oil was dissolved in ether (50 ml), washed with water (20 ml), saturated NaHCO2 (2×15 ml), brine (1×15 ml), dried Na2SO4 and evaporated in vacuo to give 2.55 g (92%) of (34) as a oil.

後処理

  1. stirringthe mixture stirred for 10 min
  2. customThe bulk of the solvent was evaporated in vacuo
  3. dissolutionThe resulting oil was dissolved in ether (50 ml)
  4. washwashed with water (20 ml), saturated NaHCO2 (2×15 ml), brine (1×15 ml), dried Na2SO4
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-f2c2ef8aac97430eba3688d429ad02ec
出典データセット
uspto-grants-1993_11
特許番号
US05262430

関連ノート

読み込み中…