Hydrochloric Acid → 4-Benzoyl-2(S)-trifluoroacetamidobutyric acid
反応式
[F:1][C:2]([F:15])([F:14])[C:3]([NH:5][C@@H:6]1[C:12](=[O:13])[O:11][C:9](=[O:10])[CH2:8][CH2:7]1)=[O:4].[Al+3].[Cl-].[Cl-].[Cl-].Cl.C(O[CH2:25][CH3:26])(=O)C>C1C=CC=CC=1>[C:9]([CH2:8][CH2:7][C@H:6]([NH:5][C:3](=[O:4])[C:2]([F:15])([F:14])[F:1])[C:12]([OH:11])=[O:13])(=[O:10])[C:26]1[CH:25]=[CH:8][CH:7]=[CH:6][CH:12]=1参加物
6
実験手順
Heat at reflux for 3 hours a mixture of N-trifluoroacetyl-L-glutamic anhydride (18.0 g, 80 mmol) and AlCl3 (23.5 g, 177 mmol) in dry benzene (400 ml). Allow to cool, treat with ice (400 ml), conc. HCl (100 ml), and ethyl acetate (EtOAc) (400 ml). Dry the organic layer and concentrate to obtain the title compound as a brown crystalline solid (25 g).
後処理
- temperatureHeat
- temperatureat reflux for 3 hours
- temperatureAllow to cool
- customDry the organic layer
- concentrationconcentrate
出典と根拠
- ORDレコード
- ord-46bd8a2309e340c792f0e0c9cc52a5c5
- 出典データセット
- uspto-grants-1993_11
- 特許番号
- US05262436
反応ノート
読み込み中…