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1,1'-(Diazomethylene)bis(benzene) → Diphenylmethyl [4-cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]-bromoacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1'-(Diazomethylene)bis(benzene) | HCID 61230 | — |
| 反応物 | [4-Cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]bromoacetic acid | HCID 18359186 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Diphenylmethyl [4-cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]-bromoacetate | HCID 53964381 | — |
反応手順
The product of Step A was dissolved in 10 ml of methylene chloride and 470 mg of diphenyl diazomethane were added. Evaporation was carried out followed by chromatography on silica (eluant: cyclohexane - ethyl acetate (2-1)) to obtain 450 mg of the desired, product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728828 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-9e556f57e168442bbbc24bcb8ff4afba |
| 出典メモ | uspto-grants-1998_03 |