Dimethyl-1,3-thiazole-5-carboxylic acid → HCID 19782022、化合物

HRID 257855ノート

反応式

HRID 257855 の反応式
[CH3:1][C:2]1[S:3][C:4]([C:8]([OH:10])=O)=[C:5]([CH3:7])[N:6]=1.[CH2:11]([O:13][C:14]1[CH:28]=[CH:27][C:17]([O:18][C:19]2[CH:26]=[CH:25][C:22]([CH2:23][NH2:24])=[CH:21][CH:20]=2)=[CH:16][CH:15]=1)[CH3:12]>C(Cl)(Cl)Cl>[CH2:11]([O:13][C:14]1[CH:28]=[CH:27][C:17]([O:18][C:19]2[CH:26]=[CH:25][C:22]([CH2:23][NH:24][C:8]([C:4]3[S:3][C:2]([CH3:1])=[N:6][C:5]=3[CH3:7])=[O:10])=[CH:21][CH:20]=2)=[CH:16][CH:15]=1)[CH3:12]

参加物

4

反応物 2

HCID 736488Dimethyl-1,3-thiazole-5-carboxylic acidHCID 196273204-(4-Ethoxyphenoxy)benzenemethanamine

生成物 1

HCID 19782022HCID 19782022、化合物収率 45%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a stirred mixture of 2,4-dimethyl-1,3-thiazole-5-carboxylic acid (156 mg, 0.993 mM) and chloroform (20 ml) was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimde (190 mg, 0.393 mM) at 0°-10° C., and the mixture was stirred for 30 min at the same temperature. To this was added a solution (10 ml) of 4-(4-ethoxyphenoxy)benzylamine (242 mg, 0.993 mM) in chloroform at 0°-10° C., and the mixture was stirred for 12 h at the room temperature. The mixture was poured into ice water, and the mixture was extracted with chloroform. The extract was washed with saturated ammonium chloride solution and brine, dried with magnesium sulfate, and concentrated in vacuo. The residue was chromatographed over silica gel to give N-[4-(4-ethoxyphenoxy)benzyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide (171 mg, 45%) as colorless crystals, m.p. 99°-101° C.

後処理

  1. additionwas added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimde (190 mg, 0.393 mM) at 0°-10° C.
  2. stirringthe mixture was stirred for 12 h at the room temperature
  3. extractionthe mixture was extracted with chloroform
  4. washThe extract was washed with saturated ammonium chloride solution and brine
  5. dry with materialdried with magnesium sulfate
  6. concentrationconcentrated in vacuo
  7. customThe residue was chromatographed over silica gel

出典と根拠

ORDレコード
ord-8dcceae3076841b6b364a8dbcc6bbe61
出典データセット
uspto-grants-1993_11
特許番号
US05264448

反応ノート

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