Allyl Mercaptan → 4-Allylsulfanylmethyl-6-(3,4-dimethoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline

HRID 25809

反応式

HRID 25809 の反応式
[CH3:1][C:2]1([CH3:21])[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7](OS(C(F)(F)F)(=O)=O)[CH:8]=2)[NH:3]1.[CH3:22][O:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][C:29]=1[O:30][CH3:31].[CH2:35]([SH:38])[CH:36]=[CH2:37]>>[CH2:35]([S:38][CH2:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:27]3[CH:26]=[CH:25][C:24]([O:23][CH3:22])=[C:29]([O:30][CH3:31])[CH:28]=3)[CH:8]=2)[NH:3][C:2]([CH3:1])([CH3:21])[CH:11]=1)[CH:36]=[CH2:37]

参加物

4

反応物 3

HCID 13367Allyl MercaptanHCID 27347023,4-Dimethoxyphenylboronic acidHCID 20760320Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester

生成物 1

HCID 102492904-Allylsulfanylmethyl-6-(3,4-dimethoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline

実験手順

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 3,4-dimethoxyphenylboronic acid. Bromination and coupling reaction with allyl mercaptan gave 10 mg of the title compound.

出典と根拠

ORDレコード
ord-68674ff6e43f4612b282d100e1703c06
出典データセット
uspto-grants-2005_02
特許番号
US06858627B2

関連ノート

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