Morpholine → Morpholine, 4-tetradecyl-

HRID 258243

反応式

HRID 258243 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>C(#N)C>[CH2:2]([N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

参加物

4

反応物 2

HCID 8083MorpholineHCID 8208Myristyl bromide

生成物 1

HCID 117616Morpholine, 4-tetradecyl-収率 94%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

In a 250-mL round bottom flask, equipped with a magnetic stirrer, a heating mantle and reflux condenser, were placed 1-bromotetradecane (15.9 g, 57.3 mmol), acetonitrile (75 mL), and morpholine (10 g, 114.7 mmol). The reaction mixture was refluxed for 4 hrs. The reaction mixture was cooled to room temperature and was concentrated to a residue on a rotary evaporator. Water and ethyl acetate were added. The organic phase was separated and washed with saturated sodium chloride solution, and then dried over anhydrous magnesium sulfate. After filtration, the solvent was evaporated to dryness affording 15.2 g (94% yield) of 4-tetradecylmorpholine as a tan oil. This intermediate was subjected to the next step without further purification.

後処理

  1. customIn a 250-mL round bottom flask, equipped with a magnetic stirrer
  2. temperaturea heating mantle and reflux condenser
  3. temperatureThe reaction mixture was refluxed for 4 hrs
  4. concentrationwas concentrated to a residue on a rotary evaporator
  5. additionWater and ethyl acetate were added
  6. customThe organic phase was separated
  7. washwashed with saturated sodium chloride solution
  8. dry with materialdried over anhydrous magnesium sulfate
  9. filtrationAfter filtration
  10. customthe solvent was evaporated to dryness

出典と根拠

ORDレコード
ord-4915d56f036b428187c79fe574ec5742
出典データセット
uspto-grants-1993_11
特許番号
US05266567

関連ノート

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