Sulfuric Acid → (2,2,2-trifluoroethoxy)acetic acid

温度

0 °C

To a solution of methyl 2-(2,2,2-trifluoroethoxy)acetate (8.26 g, 47.98 mmol) and methanol (16 mL) was added sodium hydroxide (1.92 g, 47.98 mmol) in methanol (16 mL). After stirring for 18 hours, the reaction was concentrated and ether (170 mL) was added. The mixture was cooled to 0° C. and concentrated sulfuric acid (2.15 g, 43.9 mmol) in ether (7.5 mL) was slowly added. The resulting mixture was stirred for 18 hours, filtered and concentrated to give the title compound as a colorless oil (7.15 g, 94%), MS(CI): 159(M+H); H-NMR (300 MHz, DMSO-d6): 4.14(q, J=9.3 Hz, 2H), 4.21(s, 2H), 12.92(s, 1H).

1. concentrationthe reaction was concentrated
2. additionether (170 mL) was added
3. stirringThe resulting mixture was stirred for 18 hours
4. filtrationfiltered
5. concentrationconcentrated

ORDレコード

ord-302d094745d640789173e56fca20b9cb

出典データセット

uspto-grants-1993_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05266570