Sodium Hydroxide → 2-nitromethylenetetrahydro-2H-1,3-thiazine

HRID 258550

反応式

HRID 258550 の反応式
[N+:1]([C:4](=[C:10]1[NH:15][CH2:14][CH2:13][CH2:12][S:11]1)C(OCC)=O)([O-:3])=[O:2].[OH-].[Na+]>C(O)(=O)C>[N+:1]([CH:4]=[C:10]1[NH:15][CH2:14][CH2:13][CH2:12][S:11]1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 71443329Ethyl nitro(1,3-thiazinan-2-ylidene)acetate

生成物 1

HCID 428532-nitromethylenetetrahydro-2H-1,3-thiazine

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2.3 g of 1A was added to 10 ml of 20% aqueous sodium hydroxide and the mixture was stirred at room temperature for 12 hours. The resulting solution was treated dropwise with 3.5 g of acetic acid. The addition was accompanied by vigorous gas evolution. The resulting mixture was extracted with methylene chloride and the extract was dried (magnesium sulfate) and concentrated under reduced pressure to give tetrahydro-2-(nitromethylene)-2H-1,3-thiazine (1B) as a pale yellow solid, m.p. 76°-78°.

後処理

  1. additionThe addition
  2. extractionThe resulting mixture was extracted with methylene chloride
  3. dry with materialthe extract was dried (magnesium sulfate)
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-ecbbf5c76427496194d2c544b27b633b
出典データセット
uspto-grants-1977_07
特許番号
US04033952

関連ノート

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