Sodium Hydroxide → 2-nitromethylenetetrahydro-2H-1,3-thiazine
反応式
[N+:1]([C:4](=[C:10]1[NH:15][CH2:14][CH2:13][CH2:12][S:11]1)C(OCC)=O)([O-:3])=[O:2].[OH-].[Na+]>C(O)(=O)C>[N+:1]([CH:4]=[C:10]1[NH:15][CH2:14][CH2:13][CH2:12][S:11]1)([O-:3])=[O:2]参加物
4
実験手順
2.3 g of 1A was added to 10 ml of 20% aqueous sodium hydroxide and the mixture was stirred at room temperature for 12 hours. The resulting solution was treated dropwise with 3.5 g of acetic acid. The addition was accompanied by vigorous gas evolution. The resulting mixture was extracted with methylene chloride and the extract was dried (magnesium sulfate) and concentrated under reduced pressure to give tetrahydro-2-(nitromethylene)-2H-1,3-thiazine (1B) as a pale yellow solid, m.p. 76°-78°.
後処理
- additionThe addition
- extractionThe resulting mixture was extracted with methylene chloride
- dry with materialthe extract was dried (magnesium sulfate)
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-ecbbf5c76427496194d2c544b27b633b
- 出典データセット
- uspto-grants-1977_07
- 特許番号
- US04033952
反応ノート
読み込み中…