Ethyl Acetoacetate → 3-Acetyl-7-methoxycoumarin

HRID 25873

反応式

HRID 25873 の反応式
[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:12](OCC)(=[O:17])[CH2:13][C:14]([CH3:16])=[O:15]>N1CCCCC1>[C:14]([C:13]1[C:12](=[O:17])[O:1][C:2]2[C:3]([CH:4]=1)=[CH:6][CH:7]=[C:8]([O:10][CH3:11])[CH:9]=2)(=[O:15])[CH3:16]

参加物

4

反応物 2

HCID 8868Ethyl AcetoacetateHCID 696002-Hydroxy-4-Methoxybenzaldehyde

生成物 1

HCID 20544753-Acetyl-7-methoxycoumarin

試薬・触媒・溶媒 1

HCID 8082Piperidine触媒

実験手順

A mixture of 15.2 g 2-hydroxy-4-methoxybenzaldehyde and 13.5 g ethyl acetoacetate was warmed on a hot plate until solution was attained. Thirty drops of piperidine were added and the reaction mixture continued to be heated gently. After several minutes the reaction mixture solidified. After cooling, the product was recrystallized from a mixture of alcohol and acetonitrile. Yield 20 g.

後処理

  1. temperaturewas warmed on a hot plate until solution
  2. temperatureto be heated gently
  3. waitAfter several minutes the reaction mixture solidified
  4. temperatureAfter cooling
  5. customthe product was recrystallized from a mixture of alcohol and acetonitrile

出典と根拠

ORDレコード
ord-0dc7f5bd4b6b41e582a9b7b4128509d7
出典データセット
uspto-grants-1979_04
特許番号
US04147552

関連ノート

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