Water → 4-(Methylsulfanyl)-2-nitroaniline

HRID 258758ノート

反応式

HRID 258758 の反応式
[N+:1]([C:4]1[CH:10]=[C:9]([S:11][C:12]#N)[CH:8]=[CH:7][C:5]=1[NH2:6])([O-:3])=[O:2].[OH-].[K+].CI.O>C(O)C>[CH3:12][S:11][C:9]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([N+:1]([O-:3])=[O:2])[CH:10]=1

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 1046774-Amino-3-nitrophenyl thiocyanate

生成物 1

HCID 108886074-(Methylsulfanyl)-2-nitroaniline収率 95.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Nitro-4-thiocyanato-aniline (17.6 g.) was added portionwise to a stirred solution of potassium hydroxide (13.4 g.) in ethanol (210 ml.) cooled below 15° C. After 5 minutes, methyl iodide (12.8 g.) was added to the purple solution and the mixture was allowed to stand overnight at room temperature. The mixture was then poured into water (1100 ml.) and the deep red solid was filtered off, washed with water, and dried to give 4-methylthio-2-nitroaniline (15.8 g.), m.p. 72°-73° C.

後処理

  1. temperaturecooled below 15° C
  2. waitto stand overnight at room temperature
  3. filtrationthe deep red solid was filtered off
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-5f1d566e205e4d2797ad974e92ce3565
出典データセット
uspto-grants-1977_07
特許番号
US04034107

反応ノート

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