Sodium Carbonate → 2-[3-Bis(2-hydroxyethyl)aminopropyl]amino-quinoline

HRID 258815

反応式

HRID 258815 の反応式
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[OH:12][CH2:13][CH2:14][N:15]([CH2:19][CH2:20][CH2:21][NH2:22])[CH2:16][CH2:17][OH:18].C(=O)([O-])[O-].[Na+].[Na+]>C(O)(C)C>[OH:18][CH2:17][CH2:16][N:15]([CH2:14][CH2:13][OH:12])[CH2:19][CH2:20][CH2:21][NH:22][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 119282-ChloroquinolineHCID 21088(3-Aminopropyl)diethanolamine

生成物 1

HCID 214246762-[3-Bis(2-hydroxyethyl)aminopropyl]amino-quinoline

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A mixture of 5.05 g. of 2-chloroquinoline, 5.5 g. of bis(2-hydroxyethyl)aminopropylamine and 3.0 g. of sodium carbonate is heated in 20 ml. of refluxing isopropanol for 24 hours. The reaction mixture is then filtered, solvent removed in vacuo and the residue chromatographed over silica gel to obtain an oil of 2-[3-bis(2-hydroxyethyl)aminopropyl]amino-quinoline.

後処理

  1. additionA mixture of 5.05 g
  2. filtrationThe reaction mixture is then filtered
  3. customsolvent removed in vacuo
  4. customthe residue chromatographed over silica gel

出典と根拠

ORDレコード
ord-03178fbcc19d4bcd8274cb500c301743
出典データセット
uspto-grants-1977_07
特許番号
US04035367

関連ノート

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