Sodium Hydroxide → 2-(4-Fluorophenyl)-2-(4-piperidyl)1,3-dioxolane

HRID 258850ノート

反応式

HRID 258850 の反応式
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[O:14][CH2:13][CH2:12][O:11]2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>>[F:21][C:18]1[CH:19]=[CH:20][C:15]([C:10]2([CH:7]3[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]3)[O:14][CH2:13][CH2:12][O:11]2)=[CH:16][CH:17]=1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 191009161-Acetyl-4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]piperidine

生成物 1

HCID 132790992-(4-Fluorophenyl)-2-(4-piperidyl)1,3-dioxolane収率 82%

実験手順

A mixture of 5 parts of 1-acetyl-4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]piperidine and 100 parts of sodium hydroxide solution 10% is stirred and refluxed overnight. The reaction mixture is cooled and the product is extracted with trichloromethane. The extract is dried, filtered and evaporated. The solid residue is stirred in 2,2'-oxybispropane. The product is filtered off and dried in vacuo at 40° C, yielding 3.5 parts (82%) of 4-[2(4-fluorophenyl)-1,3-dioxolan-2-yl]-piperidine.

後処理

  1. temperaturerefluxed overnight
  2. temperatureThe reaction mixture is cooled
  3. extractionthe product is extracted with trichloromethane
  4. customThe extract is dried
  5. filtrationfiltered
  6. customevaporated
  7. stirringThe solid residue is stirred in 2,2'-oxybispropane
  8. filtrationThe product is filtered off
  9. customdried in vacuo at 40° C

出典と根拠

ORDレコード
ord-6b6cfb5e52ce43b9b3dc739b52463ad8
出典データセット
uspto-grants-1977_07
特許番号
US04035369

反応ノート

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