Triethylamine → 3-(4-Methoxyphenyl)cyclobutan-1-one

HRID 258962ノート

反応式

HRID 258962 の反応式
Cl[C:2]1[C:3](=[O:14])[CH2:4][C:5]=1[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1.C(N(CC)CC)C>[Pd].CO>[CH3:13][O:12][C:9]1[CH:8]=[CH:7][C:6]([CH:5]2[CH2:4][C:3](=[O:14])[CH2:2]2)=[CH:11][CH:10]=1

参加物

5

反応物 2

HCID 8471TriethylamineHCID 214251912-Chloro-3-(p-methoxyphenyl)-2-cyclobuten-1-one

生成物 1

HCID 114466413-(4-Methoxyphenyl)cyclobutan-1-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

2-Chloro-3-(p-methoxyphenyl)-2-cyclobuten-1-one (17.4 g., 0.084 mole), triethylamine (11.7 ml., 0.084 mole), and 2.1 g. of 10% Pd/C in 300 ml. of 10% aqueous methanol is shaken under H2 (50 psi) until reduction is complete (30 min). The mixture is filtered and the filtrate evaporated. An ether solution of the residue is washed (water), dried (MgSO4), and evaporated to give 15.4 g. of an oil which is chromatographed on alumina using benzene.

後処理

  1. custom(30 min)
  2. filtrationThe mixture is filtered
  3. customthe filtrate evaporated
  4. washAn ether solution of the residue is washed (water)
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. customto give 15.4 g
  8. customof an oil which is chromatographed on alumina

出典と根拠

ORDレコード
ord-08030991e2e44713945da59fb427b3c5
出典データセット
uspto-grants-1977_07
特許番号
US04035426

反応ノート

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