Quinoline → Isoquinoline

HRID 259079

反応式

HRID 259079 の反応式
CC(OCC1CS[C@@H]2[C@H](NC(CCC[C@@H](N)C(O)=O)=O)C(=O)N2C=1C(O)=O)=O.[N:29]1[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:32]=[CH:31][CH:30]=1>[Cl-].[Na+]>[CH:38]1[C:33]2[C:32](=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:31]=[CH:30][N:29]=1

参加物

4

反応物 2

HCID 7047QuinolineHCID 65536Cephalosporin C

生成物 1

HCID 8405Isoquinoline

試薬・触媒・溶媒 1

HCID 5234Sodium Chloride溶媒

実験手順

15 ml of the remaining reaction solution were diluted with 5% sodium chloride solution to make 30 ml (corresponds to 0.5% solution calculated as cephalosporin C). After adding 0.22 ml of quinoline to the solution, the mixture was adjusted to pH 3.0 and stirred at 5 - 10° C. Very soon crystals are separated out. The crystals were collected after an hour, washed with ice-water and with ethyl acetate and dried in vacuo. 226 mg of isoquinoline adduct of N-methylthioacetyl-cephalosporin C having 97% purity were obtained.

後処理

  1. custom15 ml of the remaining reaction solution
  2. customVery soon crystals are separated out
  3. customThe crystals were collected after an hour
  4. washwashed with ice-water and with ethyl acetate
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-c9cb96fd44074840bf3b3fb02d3679d6
出典データセット
uspto-grants-1977_07
特許番号
US04036833

関連ノート

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