Quinoline → Isoquinoline
反応式
CC(OCC1CS[C@@H]2[C@H](NC(CCC[C@@H](N)C(O)=O)=O)C(=O)N2C=1C(O)=O)=O.[N:29]1[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:32]=[CH:31][CH:30]=1>[Cl-].[Na+]>[CH:38]1[C:33]2[C:32](=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:31]=[CH:30][N:29]=1参加物
4
実験手順
15 ml of the remaining reaction solution were diluted with 5% sodium chloride solution to make 30 ml (corresponds to 0.5% solution calculated as cephalosporin C). After adding 0.22 ml of quinoline to the solution, the mixture was adjusted to pH 3.0 and stirred at 5 - 10° C. Very soon crystals are separated out. The crystals were collected after an hour, washed with ice-water and with ethyl acetate and dried in vacuo. 226 mg of isoquinoline adduct of N-methylthioacetyl-cephalosporin C having 97% purity were obtained.
後処理
- custom15 ml of the remaining reaction solution
- customVery soon crystals are separated out
- customThe crystals were collected after an hour
- washwashed with ice-water and with ethyl acetate
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-c9cb96fd44074840bf3b3fb02d3679d6
- 出典データセット
- uspto-grants-1977_07
- 特許番号
- US04036833
反応ノート
読み込み中…