Sodium Hydroxide → Maltol

HRID 25909

反応式

HRID 25909 の反応式
CO[CH:3]1[O:8][CH:7]([CH3:9])[C:6](=[O:10])[CH:5]=[CH:4]1.ClCl.[OH-:13].[Na+]>C(O)(=O)C.O>[CH3:9][C:7]1[O:8][CH:3]=[CH:4][C:5](=[O:13])[C:6]=1[OH:10]

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 24526ChlorineHCID 130117926-Methoxy-2-methyl-2H-pyran-3(6H)-one

生成物 1

HCID 8369Maltol

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

A solution of 6-methoxy-2-methyl-2H-pyran-3(6H)-one (0.01 mole) in 20 ml of acetic acid was treated with gaseous chlorine (0.01 mole) at room temperature. The reaction mixture was then heated to reflux for about one hour, cooled to room temperature, diluted with 20 ml of water, the pH adjusted with 50% NaOH solution to 7.0 and the reaction mixture extracted with chloroform. The chloroform extract was concentrated to yield maltol which was recrystallized from methanol to give the pure product (56%), mp 159.5°-160.5° C.

後処理

  1. temperatureThe reaction mixture was then heated
  2. temperatureto reflux for about one hour
  3. extractionthe reaction mixture extracted with chloroform
  4. extractionThe chloroform extract
  5. concentrationwas concentrated

出典と根拠

ORDレコード
ord-7f1252b2941e457884750f3b255f5eb4
出典データセット
uspto-grants-1979_04
特許番号
US04147705

関連ノート

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