Sodium Hydroxide → Ethnor

HRID 259428

反応式

HRID 259428 の反応式
S(O)(O)(=O)=O.[C:6]1([CH:12]([N:14]2[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][N:16]=[CH:15]2)[CH3:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[OH-].[Na+]>O>[C:6]1([CH:12]([N:14]2[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][N:16]=[CH:15]2)[CH3:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 3084993Sulfuric acid--ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate (1/1)

生成物 1

HCID 36339Ethnor

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 47.5 parts of (-)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate sulfate in 500 parts of water is alkalized with 14 parts of sodium hydroxide solution 50%. The product is extracted twice with 325 parts of dichloromethane. The combined extracts are dried, filtered and evaporated in vacuo. The residue is crystallized from 2,2'-oxybispropane, yielding (-)-ethyl 1-(1-phenylethyl)-1H-imidazole- 5-carboxylate.

後処理

  1. extractionThe product is extracted twice with 325 parts of dichloromethane
  2. customThe combined extracts are dried
  3. filtrationfiltered
  4. customevaporated in vacuo
  5. customThe residue is crystallized from 2,2'-oxybispropane

出典と根拠

ORDレコード
ord-63dedf4ca74e49639e8b76e2890343a4
出典データセット
uspto-grants-1977_07
特許番号
US04038286

関連ノート

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