Hydrogen Peroxide → Chalcone epoxide

HRID 259431

反応式

HRID 259431 の反応式
[CH:1](=[CH:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:17]O.[OH-].[Na+]>CO>[C:2]1([C:1](=[O:17])[CH:8]2[O:10][CH:9]2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 784Hydrogen PeroxideHCID 7189CinnamoylbenzeneHCID 14798Sodium Hydroxide

生成物 1

HCID 92219Chalcone epoxide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a mechanically stirred mixture of 83.2 g benzalacetophenone (0.3m), 1000 ml methanol and 120 ml 15% hydrogen peroxide was added 100 ml 2N sodium hydroxide solution, while maintaining the temperature below 30° by external cooling. After completed addition, the mixture was left standing at room temperature for 20 min. The crystalline precipitate was filtered off, washed with water and recrystallized from methanol. There were obtained 59.6 g 1,3-diphenyl-2,3-epoxy-1-propanone; m.p. 90° C.

後処理

  1. temperaturewhile maintaining the temperature below 30° by external cooling
  2. additionaddition
  3. waitthe mixture was left
  4. filtrationThe crystalline precipitate was filtered off
  5. washwashed with water
  6. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-81b9796c644749a9b95c4d65aec2b733
出典データセット
uspto-grants-1977_07
特許番号
US04038289

関連ノート

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