2-(3-Nitrophenyl)oxazolo[4,5-b]pyridine → 3-(Oxazolo[4,5-b]pyridin-2-yl)aniline

HRID 259540ノート

反応式

HRID 259540 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[O:11][C:12]3[C:13]([N:18]=2)=[N:14][CH:15]=[CH:16][CH:17]=3)[CH:7]=[CH:8][CH:9]=1)([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[O:11][C:12]3[C:13]([N:18]=2)=[N:14][CH:15]=[CH:16][CH:17]=3)[CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 1

HCID 124613742-(3-Nitrophenyl)oxazolo[4,5-b]pyridine

生成物 1

HCID 6110863-(Oxazolo[4,5-b]pyridin-2-yl)aniline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 700mg. of 2-(3-nitrophenyl)oxazolo[4,5-b]pyridine in 50 ml. of ethanol was hydrogenated over 150 mg. of 5% palladium-on-carbon catalyst. The catalyst was removed by filtration and the solvent was concentrated to dryness. The residue was recrystallized from chloroformpetroleum ether to give 2-(3-aminophenyl)oxazolo[4,5-b]pyridine, m.p. 179°-180.5° C.

後処理

  1. additionA mixture of 700mg
  2. customThe catalyst was removed by filtration
  3. concentrationthe solvent was concentrated to dryness
  4. customThe residue was recrystallized from chloroformpetroleum ether

出典と根拠

ORDレコード
ord-fc2a510ad2b148efac1e78dda0e36836
出典データセット
uspto-grants-1977_07
特許番号
US04038396

反応ノート

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