Pyridine → 3-Benzoylamino-5-nitro-2-pyridone

HRID 259551ノート

反応式

HRID 259551 の反応式
[NH2:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1.N1C=CC=CC=1.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>O>[C:18]([NH:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 7412Benzoyl chlorideHCID 227547823-Amino-5-nitropyridin-2(1H)-one

生成物 1

HCID 227547673-Benzoylamino-5-nitro-2-pyridone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 100 mg. of 3-amino-5-nitro-2-pyridone in 1.5 ml. of pyridine was cooled and treated with 200 mg. of benzoyl chloride. After 2 hours water was added. The oil that separated was washed with water and triturated with ether. The resultant solid was recrystallized from ethyl acetate to give 3-benzoylamino-5-nitro-2-pyridone, m.p. 267°-268° C.

後処理

  1. additiontreated with 200 mg
  2. customThe oil that separated
  3. washwas washed with water
  4. customtriturated with ether
  5. customThe resultant solid was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-079b0e23338641ffac98174dfa2c9a3f
出典データセット
uspto-grants-1977_07
特許番号
US04038396

反応ノート

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