Nitric Acid → 3-Nitro-5-(trifluoromethyl)pyridin-2-ol
反応式
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]([F:15])([F:14])[C:7]1[CH:8]=[CH:9][C:10](=[O:13])[NH:11][CH:12]=1>>[N+:1]([C:9]1[C:10](=[O:13])[NH:11][CH:12]=[C:7]([C:6]([F:15])([F:5])[F:14])[CH:8]=1)([O-:4])=[O:2]参加物
3
実験手順
To 0.95 l. of stirred fuming nitric acid was added 29 g. of 5-trifluoromethyl-2-pyridone over 1 hour, and stirring was continued for 75 hours. The fuming nitric acid was evaporated and the residue was triturated with acetone. The acetone was evaporated to about 60 ml. and the precipitate was collected on a filter and washed with a 5:1 mixture of methylene chloride:acetone and dried and used directly in the next step.
後処理
- customThe fuming nitric acid was evaporated
- customthe residue was triturated with acetone
- customThe acetone was evaporated to about 60 ml
- customand the precipitate was collected on
- filtrationa filter
- washwashed with a 5:1 mixture of methylene chloride
- dry with materialacetone and dried
出典と根拠
- ORDレコード
- ord-eb7bdf3ca1364265b93f5ea2a2707a13
- 出典データセット
- uspto-grants-1977_07
- 特許番号
- US04038396
反応ノート
読み込み中…