2-Fluorobenzoyl chloride → 3-(2-Fluorobenzoylamino)-5-methyl-2-pyridone
反応式
[NH2:1][C:2]1[C:3](=[O:9])[NH:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[F:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13](Cl)=[O:14]>N1C=CC=CC=1>[F:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([NH:1][C:2]1[C:3](=[O:9])[NH:4][CH:5]=[C:6]([CH3:8])[CH:7]=1)=[O:14]参加物
4
実験手順
A solution of 3.1 g. of 3-amino-5-methyl-2-pyridone in 25 ml. of pyridine was cooled in ice and treated with 4.5 g. of 2-fluorobenzoyl chloride dropwise. After stirring about 3 hours at room temperature, the mixture was diluted with 200 ml. of ice-water. After 0.5 hour the precipitate was collected, washed with water, dried and recrystallized from ethanol to give 3-(2-fluorobenzoylamino)-5-methyl-2-pyridone, m.p. 230°-232° C.
後処理
- additiontreated with 4.5 g
- additionthe mixture was diluted with 200 ml
- customAfter 0.5 hour the precipitate was collected
- washwashed with water
- customdried
- customrecrystallized from ethanol
出典と根拠
- ORDレコード
- ord-baf3e9afb5e24bb095339cdbe9a88172
- 出典データセット
- uspto-grants-1977_07
- 特許番号
- US04038396
反応ノート
読み込み中…