Thionyl Chloride → HCID 12692057、化合物
反応式
[O:1]=[C:2]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:3][CH2:4][CH2:5][CH2:6][C:7](O)=[O:8].S(Cl)([Cl:18])=O>C1C=CC=CC=1>[O:1]=[C:2]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([Cl:18])=[O:8]参加物
4
実験手順
6-Oxo-6-phenylhexanoic acid (10.3g; 50 mmole), thionyl chloride (25 ml) and dry benzene (150 ml) were heated under reflux for 3 hours. The reagent and solvent were removed on the rotary evaporator. A further 100 ml of benzene was added and the solution again evaporated under reduced pressure (to remove last traces of thionyl chloride). The quantitatively formed, analytically pure brown solid (mp 53°-56°) was used directly in the Friedel-Crafts acylation of step (b).
後処理
- temperatureunder reflux for 3 hours
- customThe reagent and solvent were removed on the rotary evaporator
- additionA further 100 ml of benzene was added
- customthe solution again evaporated under reduced pressure (to remove last traces of thionyl chloride)
- customThe quantitatively formed
出典と根拠
- ORDレコード
- ord-e097c7a0636442d796e9ecf107739052
- 出典データセット
- uspto-grants-1977_07
- 特許番号
- US04038413
反応ノート
読み込み中…