Hydrochloric Acid → 4-chloro-N,2-dihydroxybenzamide

HRID 259669

反応式

HRID 259669 の反応式
Cl.[NH2:2][OH:3].C[O-].[Na+].[Cl:7][C:8]1[CH:9]=[C:10]([OH:18])[C:11](=[CH:16][CH:17]=1)[C:12](OC)=[O:13].Cl>CO>[Cl:7][C:8]1[CH:9]=[C:10]([OH:18])[C:11](=[CH:16][CH:17]=1)[C:12]([NH:2][OH:3])=[O:13]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 327085Methyl 4-chloro-2-hydroxybenzoateHCID 443297Hydroxyamine hydrochlorideHCID 10942334Sodium Methoxide

生成物 1

HCID 27818484-chloro-N,2-dihydroxybenzamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

Hydroxylamine hydrochloride (20.65 g, 0.297 mol) is added to a mixture of sodium methoxide (53 g, 0.99 mol) in methanol while maintaining the temperature below 10° C. A mixture of methyl 4-chlorosalicylate (46.2 g, 0.248 mol) in methanol is then added to the reaction mixture and the resultant mixture is stirred at room temperature for 10 days, acidified with concentrated hydrochloric acid (pH3) and filtered to give the title product as an off-white solid which is identified by NMR spectral analyses.

後処理

  1. temperaturewhile maintaining the temperature below 10° C
  2. additionis then added to the reaction mixture
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-89b5131461cb4552905ee45876d6a515
出典データセット
uspto-grants-1996_06
特許番号
US05523278

関連ノート

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