(1H-indol-2-yl)methanol → Indole-2-carboxaldehyde

HRID 259823

反応式

HRID 259823 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[CH2:10][OH:11]>C(Cl)Cl.O=[Mn]=O>[CH:10]([C:2]1[NH:1][C:9]2[C:4]([CH:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2)=[O:11]

参加物

4

反応物 1

HCID 98783(1H-indol-2-yl)methanol

生成物 1

HCID 96389Indole-2-carboxaldehyde

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6344Dichloromethane溶媒

実験手順

A total of 1.76 g of 2-indolemethanol was dissolved in dry CH2Cl2 (20 mL) at room temperature and stirred overnight with MnO2 (2.1 g, 24 mmol). The mixture was filtered through Celite, the filtrate was evaporated under reduced pressure, and the product was purified by flash chromatography (CH2Cl2). Yield: 1.31 g (75%), 1H NMR (CDCl3): δ7.1-7.5 (m, 4H), 7.76 (d, 1H, J=7.8 Hz), 9.41 (br s, 1H), 9.86 (s, 1H).MS EI): m/z 145 (M+).

後処理

  1. filtrationThe mixture was filtered through Celite
  2. customthe filtrate was evaporated under reduced pressure
  3. customthe product was purified by flash chromatography (CH2Cl2)

出典と根拠

ORDレコード
ord-60ef377f2f62446ba45f801c0bb4075c
出典データセット
uspto-grants-1996_06
特許番号
US05523411

関連ノート

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