2-Fluoro-5-methoxybenzoic acid → 2-Fluoro-5-hydroxybenzoic acid

HRID 259934

反応式

HRID 259934 の反応式
[F:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]([O:11]C)=[CH:4][CH:3]=1>Br>[F:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]([OH:11])=[CH:4][CH:3]=1

参加物

3

反応物 1

HCID 27745432-Fluoro-5-methoxybenzoic acid

生成物 1

HCID 27744802-Fluoro-5-hydroxybenzoic acid

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

反応条件

温度
100 °C

実験手順

6-Fluoro-3-methoxybenzoic acid (500 mg, 2.94 mmol) was mixed with freshly distilled 48% HBr (20 mL) and heated at 100° C. for 14 h. Water and HBr were evaporated and the crude product (462 mg) was used without further purification. 1H NMR(CD3OD): δ7.28-7,29 (m, 1H), 6.92-7.12 (m, 2H); 13C NMR (CD3OD): δ167.80, 157.26 (d, J=249 Hz), 154.77, 122.52 (d, J=10.4 Hz), 120.49 (d, J=11 Hz), 118.77 (d, J=19 Hz), 118.58.

後処理

  1. customWater and HBr were evaporated
  2. customthe crude product (462 mg) was used without further purification

出典と根拠

ORDレコード
ord-2b17b083510b4baca035fa35dd56b075
出典データセット
uspto-grants-1996_06
特許番号
US05523475

関連ノート

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