Ethanol → Etilevodopa

HRID 260088

反応式

HRID 260088 の反応式
[CH:1]1[C:6]([CH2:7][C@H:8]([NH2:12])[C:9]([OH:11])=[O:10])=[CH:5][C:4]([OH:13])=[C:3]([OH:14])[CH:2]=1.S(Cl)(Cl)=O.[CH2:19](O)[CH3:20]>>[CH3:19][CH2:20][O:10][C:9]([C@@H:8]([NH2:12])[CH2:7][C:6]1[CH:1]=[CH:2][C:3]([OH:14])=[C:4]([OH:13])[CH:5]=1)=[O:11]

参加物

4

反応物 3

HCID 702EthanolHCID 6047LevodopaHCID 24386Thionyl Chloride

生成物 1

HCID 170345Etilevodopa

反応条件

温度
40 °C

実験手順

Levodopa (50 g.) was added in portions to a cooled (2°-8° C.) solution of 30 ml. thionyl chloride in 250 ml. absolute ethanol. The resulting mixture was heated to 40° C. for 16 hours and then the volatiles were removed in vacuo. The residue was dissolved in 50 ml. of water and diluted with a solution of 20 g. of sodium bicarbonate, 26 g. of sodium sulfate and 50 mg. of ascorbic acid in 400 ml. of water. The pH of the resulting solution was carefully adjusted to pH 7 with 10% aqueous sodium hydroxide and it was extracted with deaerated ethyl acetate containing 0.01% BHT.

後処理

  1. temperaturea cooled (2°-8° C.) solution of 30 ml
  2. customthe volatiles were removed in vacuo
  3. dissolutionThe residue was dissolved in 50 ml
  4. additionof water and diluted with a solution of 20 g
  5. extractionwas extracted with deaerated ethyl acetate containing 0.01% BHT

出典と根拠

ORDレコード
ord-048a27d93e4c4f6f8b946eff6e3590d8
出典データセット
uspto-grants-1996_06
特許番号
US05525631

関連ノート

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