Valproic Acid → 2-Propylvaleryl chloride
反応式
[C:1]([OH:10])(=O)[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].S(Cl)([Cl:13])=O>C1C=CC=CC=1>[C:1]([Cl:13])(=[O:10])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To 4.32 g (30 mmol) of valproic acid in an ice bath, thionyl chloride (3.60 g, 30 mmol) was slowly added, with stirring. The neat mixture was allowed to come to room temperature and then heated in a water bath at 50° C. for 30 minutes. 50 M1 portions of dry benzene were twice added and removed under reduced pressure. The resultant product was used in subsequent reactions without further purification.
後処理
- customto come to room temperature
- customremoved under reduced pressure
- customThe resultant product was used in subsequent reactions without further purification
出典と根拠
- ORDレコード
- ord-7062ea72074043e7bf4ec57d183adc6d
- 出典データセット
- uspto-grants-1996_06
- 特許番号
- US05525727
反応ノート
読み込み中…