Valproic Acid → 2-Propylvaleryl chloride

HRID 260201

反応式

HRID 260201 の反応式
[C:1]([OH:10])(=O)[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].S(Cl)([Cl:13])=O>C1C=CC=CC=1>[C:1]([Cl:13])(=[O:10])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5]

参加物

4

反応物 2

HCID 3121Valproic AcidHCID 24386Thionyl Chloride

生成物 1

HCID 762402-Propylvaleryl chloride

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
50 °C

実験手順

To 4.32 g (30 mmol) of valproic acid in an ice bath, thionyl chloride (3.60 g, 30 mmol) was slowly added, with stirring. The neat mixture was allowed to come to room temperature and then heated in a water bath at 50° C. for 30 minutes. 50 M1 portions of dry benzene were twice added and removed under reduced pressure. The resultant product was used in subsequent reactions without further purification.

後処理

  1. customto come to room temperature
  2. customremoved under reduced pressure
  3. customThe resultant product was used in subsequent reactions without further purification

出典と根拠

ORDレコード
ord-7062ea72074043e7bf4ec57d183adc6d
出典データセット
uspto-grants-1996_06
特許番号
US05525727

関連ノート

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