Boc-Gly-Gly-Ala-Pro-OBzl → Boc-Gly-Gly-Ala-Pro-OH

HRID 260250ノート

反応式

HRID 260250 の反応式
[NH:1]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][C@H:10]([C:12]([N:14]1[CH2:28][CH2:27][CH2:26][C@H:15]1[C:16]([O:18]CC1C=CC=CC=1)=[O:17])=[O:13])[CH3:11])=[O:8])=[O:4]>C(O)(=O)C.[Pd]>[NH:1]([C:29]([O:31][C:32]([CH3:33])([CH3:35])[CH3:34])=[O:30])[CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][C@H:10]([C:12]([N:14]1[CH2:28][CH2:27][CH2:26][C@H:15]1[C:16]([OH:18])=[O:17])=[O:13])[CH3:11])=[O:8])=[O:4]

参加物

4

反応物 1

HCID 131719402Boc-Gly-Gly-Ala-Pro-OBzl

生成物 1

HCID 53321812Boc-Gly-Gly-Ala-Pro-OH

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

Boc-Gly-Gly-Ala-Pro-OBzl (30.0 g, 0.061 mole) was dissolved in glacial acetic acid (300 mL) and 3.0 g of 10% Palladium on activated charcoal was added. This mixture was hydrogenated at 40 psi for 6 h. The reaction mixture was filtered through celite and the solvent was removed in vacuum. The resulting residue was triturated with ether, faltered, washed with ether, and dried to obtain Boc-Gly-Gly-Ala-Pro-OH.

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe solvent was removed in vacuum
  3. customThe resulting residue was triturated with ether
  4. washwashed with ether
  5. customdried

出典と根拠

ORDレコード
ord-ba75f07f17344df7bdaa8bafc0bdb6dc
出典データセット
uspto-grants-1996_06
特許番号
US05527610

反応ノート

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