Phenol → 1-Naphthyloxy proline amide

反応式

FC(F)(F)C(O)=O.C([NH:12][C:13](=[O:26])[C@@H:14]1[CH2:18][C@H:17](OC2C=CC=CC=2)[CH2:16][NH:15]1)(C)(C)C.[C:27]1([OH:37])[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][CH:28]=1.C1(O)C=CC=CC=1>>[C:27]1([O:37][N:15]2[CH2:16][CH2:17][CH2:18][C@H:14]2[C:13]([NH2:12])=[O:26])[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][CH:28]=1

参加物

反応物 3

HCID 996Phenol

HCID 70051-Naphthol

HCID 22862000n-t-Butyl-4(s)-phenoxy-l-prolineamide trifluoroacetic acid salt

生成物 1

HCID 228619921-Naphthyloxy proline amide

実験手順

Following substantially the same procedure for synthesizing N-t-butyl-4(S)-phenoxy-L-prolineamide trifluoroacetic acid salt as outlined in Example 1, Steps 6 through 8, but substituting 1-naphthol for the phenol used therein, the 1-naphthyloxy proline amide was produced.

出典と根拠

ORDレコード: ord-1bdfafd9470c41ff803e450f62e2f2bc
出典データセット: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05527799

反応ノート

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