Thiophenol → 5-Fluoro-3-[1-hydroxy-2-methyl-1-(thiazol-2-yl)propyl]thiophenol
反応式
C1([SH:7])C=CC=CC=1.F[C:9]1[CH:10]=[C:11]([C:16]([C:18]2[S:19][CH:20]=[CH:21][N:22]=2)=[O:17])[CH:12]=[C:13]([F:15])[CH:14]=1.[CH:23]([Mg]Br)([CH3:25])[CH3:24].C([Mg]Br)=C>C1COCC1>[F:15][C:13]1[CH:12]=[C:11]([C:16]([OH:17])([C:18]2[S:19][CH:20]=[CH:21][N:22]=2)[CH:23]([CH3:25])[CH3:24])[CH:10]=[C:9]([SH:7])[CH:14]=1参加物
6
実験手順
Following the procedure described for Thiophenol 2, Step 3 and Thiophenol 5, Steps 2 and 3 but substituting the ketone from Thiophenol 5, Step 1 for (3,5-difluorophenyl)(thiazol-2-yl)-methanone and isopropylmagnesium bromide (Aldrich) in THF for vinylmagnesium bromide as starting material the title compound was obtained.
出典と根拠
- ORDレコード
- ord-ee43bc2193294dfcbe326ab381d6dd94
- 出典データセット
- uspto-grants-1996_06
- 特許番号
- US05527827
反応ノート
読み込み中…