Thiophenol → 5-Fluoro-3-[1-hydroxy-1-(thiazol-2-yl)propyl]thiophenol
反応式
C1([SH:7])C=CC=CC=1.F[C:9]1[CH:10]=[C:11]([C:16]([C:18]2[S:19][CH:20]=[CH:21][N:22]=2)=[O:17])[CH:12]=[C:13]([F:15])[CH:14]=1.[CH2:23]([Mg]Br)[CH3:24].C([Mg]Br)=C>C1COCC1>[F:15][C:13]1[CH:12]=[C:11]([C:16]([OH:17])([C:18]2[S:19][CH:20]=[CH:21][N:22]=2)[CH2:23][CH3:24])[CH:10]=[C:9]([SH:7])[CH:14]=1参加物
6
実験手順
Following the procedure described for Thiophenol 2, Step 3 and thiophenol 5, Steps 2 and 3 but substituting the ketone from Thiophenol 5, Step 1 for (3,5-difluorophenyl)(thiazol-2-yl)methanone and ethylmagnesium bromide in THF (Aldrich) for vinylmagnesium bromide as starting material the title compound was obtained. Mass spec. 270 (MH+).
出典と根拠
- ORDレコード
- ord-7c59a03e32054839bb55be7f48d8e39e
- 出典データセット
- uspto-grants-1996_06
- 特許番号
- US05527827
反応ノート
読み込み中…