3-Benzenesulfonyl-5-chloroindole-2-carboxamide → 5-chloro-3-(phenylsulfonyl)-1H-Indole-2-carbonitrile

HRID 260494ノート

反応式

HRID 260494 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([NH2:13])=O)=[C:5]2[S:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=[O:16])=[O:15].[OH-].CCC[N+](S(=O)(=O)NC(O)=O)(CC)CC>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]#[N:13])=[C:5]2[S:14]([C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)(=[O:16])=[O:15]

参加物

4

反応物 2

HCID 4548443-Benzenesulfonyl-5-chloroindole-2-carboxamideHCID 86749577Methyl (carboxysulfamoyl)triethylammonium hydroxide

生成物 1

HCID 224015145-chloro-3-(phenylsulfonyl)-1H-Indole-2-carbonitrile

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

5-Chloro-3-phenylsulfonylindole-2-carboxamide reacts with methyl (carboxysulfamoyl)triethylammonium hydroxide inner salt (Burgess reagent) in tetrahydrofuran (THF) solvent as described by D. A. Claremon and B. T. Phillips (Tetrahedron Lett., 29, 2155 (1988)) to provide the title compound.

出典と根拠

ORDレコード
ord-0b1fe20c76aa419b99e691b77546a0e6
出典データセット
uspto-grants-1996_06
特許番号
US05527819

反応ノート

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