1-(1-Naphthyl)piperazine → 4-[(5-Methoxy-1H-inden-3-yl)acetyl]-1-(naphth-1-yl)piperazine

HRID 260663

反応式

HRID 260663 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]=[C:6]2[CH2:12][C:13]([OH:15])=O.[C:16]1([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][CH:17]=1>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]=[C:6]2[CH2:12][C:13]([N:29]1[CH2:28][CH2:27][N:26]([C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][CH:17]=2)[CH2:31][CH2:30]1)=[O:15]

参加物

4

反応物 2

HCID 13421-(1-Naphthyl)piperazineHCID 344495(5-Methoxy-1h-inden-3-yl)acetic acid

生成物 1

HCID 224002654-[(5-Methoxy-1H-inden-3-yl)acetyl]-1-(naphth-1-yl)piperazine収率 86.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

2.0 g (0.012 mol) of N,N'-carbonyldiimidazole are added in small portions to a solution of 2.45 g (0.012 mol) of 5-methoxy-1H-indene-3-acetic acid in 12 ml of tetrahydrofuran, which has been placed under an argon atmosphere, and the mixture is stirred for 1 h. A solution of 2.55 g (0.012 mol) of 1-(naphth-1-yl)piperazine in 10 ml of tetrahydrofuran is added, and the mixture is left to stand overnight. The solvent is evaporated under reduced pressure. The residual oil is taken up in water and diethyl ether, and the solid obtained is collected by filtration and dried. 4.13 g of a product are obtained which is used as it is in the following step.

後処理

  1. waitthe mixture is left
  2. waitto stand overnight
  3. customThe solvent is evaporated under reduced pressure
  4. customdiethyl ether, and the solid obtained
  5. filtrationis collected by filtration
  6. customdried

出典と根拠

ORDレコード
ord-40081900ff45423ebdeb1b2631622840
出典データセット
uspto-grants-1996_06
特許番号
US05530002

関連ノート

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