Methanol → 1,2-Dimethylpropylamine

HRID 260798

反応式

HRID 260798 の反応式
C[OH:2].[CH3:3][CH:4]([NH:8][C:9]1[C:12](=[O:13])[C:11](=[O:14])[C:10]=1[NH:15][C:16]1[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=1)[CH:5]([CH3:7])[CH3:6].[C:24](#N)[CH3:25]>>[O:13]=[C:12]1[C:9](=[O:2])[C:10]([NH:15][C:16]2[CH:17]=[CH:18][C:19]([C:20]#[N:21])=[CH:22][CH:23]=2)=[C:11]1[O:14][CH2:24][CH3:25].[CH3:3][CH:4]([NH2:8])[CH:5]([CH3:7])[CH3:6]

参加物

5

反応物 3

HCID 887MethanolHCID 6342AcetonitrileHCID 106129714-[2-(1,2-Dimethyl-propylamino)-3,4-dioxo-cyclobut-1-enylamino)-benzonitrile

生成物 2

HCID 117311,2-DimethylpropylamineHCID 108240584-[(2-Ethoxy-3,4-dioxocyclobut-1-en-1-yl)amino]benzonitrile

実験手順

This compound was prepared according to the procedure described in Example 11, first paragraph. 4-(3,4-Dioxo-2-ethoxy-cyclobut-1-enylamino)-benzonitrile (1 g, 4.1 mmol) and (±)-1,2-dimethylpropylamine (5 g, 57.4 mmol) in acetonitrile (125 mL) there was obtained after trituration with methanol 0.28 g (24%) of 4-[2-(1,2-dimethyl-propylamino)-3,4-dioxo-cyclobut-1-enylamino)-benzonitrile as a yellow solid: mp 222°-224° C.; 1H NMR (DMSO-d6): δ 9.89 (br s, 1H), 7.78 (d, 2H), 7.73 (d, 1H), 7.59 (d, 2H), 3.98 (m, 1H), 1.76 (m, 1H), 1.19 (d, 3H), 0.90 (d, 3H), 0.89 (d, 3H). IR (KBr): 2980, 2240, 1799, 1660, 1600, 1565, 1525 cm-1 ; MS (m/z) 283 (M+).

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-dcad9259b41849488d277117640f9569
出典データセット
uspto-grants-1996_06
特許番号
US05530025

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