Ammonia → HCID 178419104、化合物

HRID 261059ノート

反応式

HRID 261059 の反応式
Cl.[C:2](=[NH:9])(OCC)[CH:3]([CH3:5])[CH3:4].[NH3:10].[OH2:11].[C:12]1([CH3:18])[CH:17]=[CH:16]C=CC=1>CN(C)C>[CH:3]([C:2]1[N:9]=[C:12]([CH3:18])[CH:17]=[C:16]([OH:11])[N:10]=1)([CH3:5])[CH3:4]

参加物

6

反応物 4

HCID 222AmmoniaHCID 962WaterHCID 1140Toluene2 回HCID 12816252Ethyl 2-methylpropanimidate--hydrogen chloride (1/1)

生成物 1

HCID 178419104HCID 178419104、化合物

試薬・触媒・溶媒 1

HCID 1146Trimethylamine溶媒2 回

実験手順

The method according to claim 1 wherein ethyl isobutyrimidate hydrochloride is neutralized by trimethylamine dissolved in toluene, the free ethyl isobutyrimidate is freed from water by azeotropic distillation; then the dry ethyl isobutyrimidate in toluene is reacted with an excess of diketene dissolved in toluene in the presence of trimethylamine and the resulting organic solution is treated with gaseous ammonia, in molar equivalent amounts and subsequent azeotropic removal of water to form 2-isopropyl-4-methyl-6-hydroxypyrimidine which is dried and recovered from said organic solvent.

後処理

  1. distillationthe free ethyl isobutyrimidate is freed from water by azeotropic distillation
  2. customthen the dry ethyl isobutyrimidate in toluene is reacted with an excess of diketene

出典と根拠

ORDレコード
ord-d986d003f8234d2b8dbbaac6d7f06df9
出典データセット
uspto-grants-1979_08
特許番号
US04163848

反応ノート

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