2,6-Dichloropyrazine → 4-(6-Chloropyrazin-2-yl)piperazin-2-one

HRID 261060ノート

反応式

HRID 261060 の反応式
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[O:9]=[C:10]1[CH2:15][NH:14][CH2:13][CH2:12][NH:11]1>C(#N)C>[Cl:8][C:4]1[N:3]=[C:2]([N:14]2[CH2:13][CH2:12][NH:11][C:10](=[O:9])[CH2:15]2)[CH:7]=[N:6][CH:5]=1

参加物

4

反応物 2

HCID 785042,6-DichloropyrazineHCID 231360Piperazin-2-one

生成物 1

HCID 203960024-(6-Chloropyrazin-2-yl)piperazin-2-one

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 10.0 g (0.0067 mole) of 2,6-dichloropyrazine and 14 g (0.14 mole) of 2-oxopiperazine in 100 ml of acetonitrile is refluxed 1.5 hour with stirring under N2. The mixture is concentrated under vacuum, the residue titrated with water and filtered, and the crude solid recrystallized from water (charcoal treatment) to give off-white plates of the subject compound, 7.7 g, mp 192°-193° C.

後処理

  1. temperatureis refluxed 1.5 hour
  2. concentrationThe mixture is concentrated under vacuum
  3. filtrationfiltered
  4. customthe crude solid recrystallized from water (charcoal treatment)
  5. customto give off-white plates of the subject compound, 7.7 g, mp 192°-193° C.

出典と根拠

ORDレコード
ord-fbaa38e21c5b4138988186de4e3cf619
出典データセット
uspto-grants-1979_08
特許番号
US04163849

反応ノート

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