Methyl iodide → 3,5-diamino-1-methyl-1H-pyrazole-4-carbonitrile

HRID 261072ノート

反応式

HRID 261072 の反応式
[NH2:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([NH2:9])[NH:4][N:3]=1.IC.[C:12](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[NH2:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([NH2:9])[N:4]([CH3:12])[N:3]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 142021413,5-Diamino-1H-pyrazole-4-carbonitrile

生成物 1

HCID 126210283,5-diamino-1-methyl-1H-pyrazole-4-carbonitrile収率 16.2%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

3,5-Diamino-4-cyanopyrazole (6.1 g) prepared as in Example 3, iodomethane (3.1 ml), anhydrous potassium carbonate (7.6 g) and acetone (120 ml) were heated under reflux for 18 hours. The mixture was filtered, and the filtrate was concentrated to a viscous oil. Trituration of the oil with water gave a precipitate of 3,5-diamino-4-cyano-1-methylpyrazole (1.1 g), m.p. 194°-196° C.

後処理

  1. temperaturewere heated
  2. temperatureunder reflux for 18 hours
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate was concentrated to a viscous oil

出典と根拠

ORDレコード
ord-027954cc5b4a46fdabac1c15a9c3705b
出典データセット
uspto-grants-1979_08
特許番号
US04163846

反応ノート

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